Page Zero in APEX is a powerful tool. For the uninformed, it allows you to put APEX components on it and have them render on every other page in your application - unless conditionally set to do otherwise. Components supported on page zero include regions, items, buttons, branches, computations and dynamic actions.
For years now, anytime that I needed a region or item or button on more than one page, I would put it on page zero, and if needed set the condition to display as needed. It saved a lot of time, as I would only need to create the component once, and was a lot easier to manage as there was only one copy for multiple pages. As you needed that component to render on additional pages, all that was required was a small change to the condition.
Thus, the combination of Dynamic Actions on Page Zero is quite powerful, as once you define a Dynamic Action, it would be available on each and every page. Add a couple of Dynamic Action Plugins to the mix, and you can create some powerful, reusable components in your APEX applications.
But like almost anything else, too much of a good thing is also bad for you. I recently started using a plugin that allows you to pop open a region on a page via dynamic action in sumnevSERT. Initially, our requirements were simple - show a single region and allow the user to edit a couple of fields. But as development progressed, the requirements got more and more sophisticated. In some cases, the region needed multiple conditional items and even a report.
At this time, we took a step back and had a look at page 0, and it was a mess. Over 30 dynamic actions, several regions, items and buttons - all of which would render on almost every page - were present. Since we didn't know which dynamic action or region would be required, we had to render most of them on most of the pages in the application, thus reducing performance and adding a whole lot of complexity.
We fast realized that there had to be a better way. After some research, we found a different plugin that supported popups based on pages, not regions. While it did take some re-tooling, it was a lot easier to manage these popups as individual pages, as development could use almost all default functionality and require few, if any, conditional components. Since the page would only render when requested, the application became much more efficient. We reduced the number of dynamic actions on page 0 to 8 and eliminated all additional regions, items and buttons. This was a huge savings not only for immediate performance, but for overall manageability of the application.
Lessons learned here - don't get too attached to any specific plugin or technique that you become blinded by it. I've often advocated the use of page 0 and will continue to do so, but that recommendation should be taken as such, not as an absolute rule that can not be bent. If you find yourself in the same scenario, it may be time to retool your approach as well.